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Obesity Management During Reproductive Years
Clinical Queries: Expert Insights to Improve Obesity Management During Reproductive Years 

Released: January 20, 2026

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Leah lost 25 lb (11 kg) over 9 months with 10-mg/week tirzepatide. She and her partner decided to start trying to conceive, and she would like your advice on discontinuing tirzepatide. You advise her that weight regain is common after stopping AOMs, including tirzepatide.

What would you provide as the best advice, based on available evidence, for mitigating weight regain?