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Obesity Management During Reproductive Years
Clinical Queries: Expert Insights to Improve Obesity Management During Reproductive Years 

Released: January 20, 2026

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After discussing obesity management goals, you and Michelle decided that a target of 5% to 10% weight loss through intensified lifestyle management would be a good place to start. She enrolled in a weight loss program focused on intensive lifestyle management, and after 6 months, she has lost 5% of her initial body weight (10 lb [4.5 kg]), her waist circumference is 45 in (114 cm), and her BMI is 31.4 kg/m2. She’s seen improvements in her blood pressure (128/76 mmHg), blood glucose (A1C 5.8%), LDL-C (140 mg/dL), and triglycerides (160 mg/dL), but they are still borderline high. Her HDL-C, OSA, and menstrual cycle have not noticeably improved. Michelle is encouraged because she has been able to lose some weight, but it seems like her weight loss has plateaued. She and her partner are talking about trying for pregnancy in the next 1-2 years, and she would like to add an AOM to lose as much weight as she can and further improve her health before trying to conceive. She would still ideally like to reach 20% weight loss from her starting body weight, approximately 20 lb (9 kg) more than what she’s lost so far.

Which AOM would you recommend for Michelle?