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ARIA Training Module

CE / CME

Spot the Signal: Global Radiology Training for ARIA Detection in Alzheimer’s Care

Physician Assistants/Physician Associates: 1.00 AAPA Category 1 CME credit

Physicians: Maximum of 1.00 AMA PRA Category 1 Credit

European Learners: 1.00 EBAC® CE Credit

Released: April 16, 2026

Expiration: April 15, 2027

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Case 1: Eligibility and Baseline Assessment

Dr Benzinger:

In this case, an 83-year-old woman presented with memory loss. She lived alone in a freestanding house and remained independent in activities of daily living (ADLs), including cooking, shopping, and laundry. Her Mini-Mental State Exam (MMSE) score was 27/30, and her Clinical Dementia Rating (CDR) was 0.5, both of which indicate questionable to very mild cognitive impairment, so this patient is very early in the disease process.12 The information about her ADLs and living independently is also a component of the CDR. For many families, the goal of therapy is maintaining independence as this patient currently is, so enabling her to continue for as long as possible would be important.

The other important features include current medications, particularly anticoagulants or antiplatelets, since these will further increase risk for hemorrhages, and APOE genotype. The APOE4 variant is associated with a higher risk of ARIA, and in some places, including in the Veterans Administration system in the United States, homozygous APOE4 carriers may not be eligible for ATT because of the increased vascular amyloid risk.

Dr Lövblad:

As mentioned above, it is also the case in Europe that homozygous APOE4 carriers are not eligible for ATTs according to regulatory indications.

  • 83-year-old female with memory loss
  • Mini-Mental Status Exam (MMSE) 27/30
  • Clinical Dementia Rating (CDR) 0.5
  • Florbetapir amyloid PET positive

Would you report that this patient is eligible for treatment with amyloid-targeting therapy?