Content - Therapies for Cancer Cachexia | Decera Clinical Education

Introduction

In this module, Jeffrey Crawford, MD, reviews current pharmacologic guidelines and the rationale and available evidence supporting the investigation of new and emerging therapeutic strategies for the optimal management of patients with advanced cancer and cachexia. These topics were presented by Dr Crawford during a previously held live virtual webinar, titled: Global Expert Think Tank: Hope on the Horizon? Key Evidence and Real-world Insights to Optimize the Diagnosis and Treatment of Cancer Cachexia.

Please note that the key points discussed in this module are illustrated with thumbnails from an accompanying downloadable PowerPoint slideset, which can be found here or downloaded by clicking any of the slide thumbnails in the module alongside the expert commentary.

Decera Clinical Education plans to measure the educational impact of this activity. A few questions will be asked twice: once at the beginning of the activity and then again after the discussion that informs the best choice. Your responses will be aggregated for analysis, and your specific responses will not be shared.

Before continuing with this educational activity, please take a moment to answer the following questions.

How many people with cancer do you provide care for in a typical month?

A.
1-4
B.
5-10
C.
11-15
D.
16-20
E.
>20
F.
Not applicable

For those who practice in academic or community settings, please indicate your practice setting:

A.
Academic
B.
Community
C.
Not applicable

In patients with advanced cancer and significant weight loss, how is ponsegromab thought to contribute to a multimodal cancer cachexia management plan?

A.
By stimulating ghrelin receptors to directly promote anabolic activity and increase lean body mass
B.
By blocking the growth differentiation factor 15 (GDF-15)/glial cell–derived neurotrophic factor receptor alpha-like (GFRAL) pathway, thereby restoring appetite regulation and reducing catabolic signaling
C.
By acting as an anti-inflammatory agent that inhibits interleukin-6 and lowers C-reactive protein levels
D.
By serving as a β-adrenergic antagonist to reduce metabolic rate and prevent further weight loss

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Current, Novel and Emerging Therapies on the Horizon for Cancer Cachexia

Jeffrey Crawford, MD

Activity

Introduction

How many people with cancer do you provide care for in a typical month?

For those who practice in academic or community settings, please indicate your practice setting:

In patients with advanced cancer and significant weight loss, how is ponsegromab thought to contribute to a multimodal cancer cachexia management plan?