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Case Challenge: NSCLC

CE / CME

Biomarker Testing in Patients With Solid Tumors: Interactive Case Challenge for NSCLC

Nurse Practitioners/Nurses: 0.50 Nursing contact hours, includes 0.50 hour of pharmacotherapy credit

Physician Assistants/Physician Associates: 0.50 AAPA Category 1 CME credit

Released: June 16, 2026

Expiration: December 15, 2026

Activity

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Course Completed

Patient History/Initial Presentation
A 75-year-old man presents with progressive shortness of breath, cough, weight loss, and fatigue over the past 3-6 months. He smoked 1 pack per day for about 45 years but quit 10 years ago. Workup imaging of chest shows a central right upper lobe lung mass with bulky mediastinal lymphadenopathy, liver metastases, and brain metastases. Biopsy confirms metastatic lung adenocarcinoma.

His PD-L1 expression returns at 50%, but broad-panel NGS is still pending. He is symptomatic and anxious to begin treatment quickly. His wife is with him and is very encouraged by the high PD-L1 result. She asks whether pembrolizumab might be an option based on what she has heard in the media.

What would you tell this patient and his wife about the next step in his care based on his current condition?