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EGFRm NSCLC Brain Metastases

CE / CME

Management of a Patient With EGFR-Mutated NSCLC and Brain Metastases

Physician Assistants/Physician Associates: 0.50 AAPA Category 1 CME credit

Pharmacists: 0.50 contact hour (0.05 CEUs)

Physicians: maximum of 0.50 AMA PRA Category 1 Credit

Nurse Practitioners/Nurses: 0.50 Nursing contact hour

Released: May 04, 2026

Expiration: November 03, 2026

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Case Follow-up
After 3 weeks of corticosteroid treatment and taper, her symptoms resolve, oxygen returns to baseline, and repeat CT shows resolution of the multifocal ground-glass opacities. The event is classified as grade 2 ILD/pneumonitis.

During treatment, she also develops grade 1 stomatitis that is managed with intensified oral supportive care, including increased use of steroid-containing mouthwash, while she continues therapy without dose interruption.

Now that her symptoms and imaging have improved, what would you recommend regarding Dato-DXd?