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EGFRm NSCLC Brain Metastases

CE / CME

Management of a Patient With EGFR-Mutated NSCLC and Brain Metastases

Physician Assistants/Physician Associates: 0.50 AAPA Category 1 CME credit

Pharmacists: 0.50 contact hour (0.05 CEUs)

Physicians: maximum of 0.50 AMA PRA Category 1 Credit

Nurse Practitioners/Nurses: 0.50 Nursing contact hour

Released: May 04, 2026

Expiration: November 03, 2026

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Case Follow-up
Because the symptomatic brain lesion needs to be addressed promptly, resistance testing is pursued in parallel. Plasma ctDNA and liver biopsy ultimately do not reveal a new actionable resistance alteration or histologic transformation.

What is the best next step in management of her brain metastases?