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Q&A on Oral Targeted Therapies in HR+/HER2- Breast Cancer for Oncology Pharmacists

Clinical Thought

Oral targeted therapies have expanded treatment options for patients with HR-positive/HER2-negative breast cancer, but biomarker results, prior treatment exposure, toxicity risk, and adherence challenges can complicate long-term treatment planning. This activity uses practical expert Q&A to examine biomarker-guided treatment selection, sequencing of targeted therapies, adverse event prevention and management, dose modification, and strategies to support adherence and treatment persistence.

Released: July 28, 2026

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Provided by ProCE, LLC.

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Supporters

Supported by an educational grant from AstraZeneca.

AstraZeneca

Target Audience

This activity has been designed to meet the educational needs of oncology pharmacists and other healthcare professionals caring for patients with breast cancer.

Learning Objectives

Upon completion of this activity, participants should be able to:

  • Apply the latest safety and efficacy evidence for oral targeted therapies to clinical practice to individualize the management of patients with HR-positive/HER2-negative breast cancer

  • Collaborate with patients, caregivers, and the multidisciplinary team to use evidence-based approaches for monitoring and managing adverse events associated with oral targeted therapies for HR-positive/HER2-negative breast cancer

  • Support adherence and persistence to oral targeted therapies in patients with HR-positive/HER2-negative breast cancer through expert-recommended communication strategies, tools, and resources

Financial Disclosures

Primary Author

Jordan Hill, PharmD, BCOP, has no relevant financial relationships to disclose.

Danielle Roman, PharmD, BCOP: consultant/advisor/speaker: Daiichi Sankyo, Genentech, Pfizer, Regeneron.

Additional Disclosures

Generative artificial intelligence (AI) tools were used for drafting educational content and revising or refining educational content. All AI-assisted content underwent human review, editing, and validation by qualified faculty and accredited education staff to ensure scientific accuracy, balance, and compliance with the ACCME Standards for Integrity and Independence in Accredited Continuing Education.