Content - ESMO 2025 Lung Cancer | Decera Clinical Education

Introduction

In this text-based module, Luis Paz-Ares, MD, PhD, and David Planchard, MD, PhD, discuss key findings in lung cancer presented at the 2025 European Society For Medical Oncology (ESMO) Annual Meeting.

The key points discussed in this module are illustrated with thumbnails from the accompanying downloadable PowerPoint slidesets, which can be found here or downloaded by clicking any of the slide thumbnails in the module alongside the expert commentary.

Decera Clinical Education plans to measure the educational impact of this activity. The questions will be asked twice: once at the beginning of the activity and then once again after the discussion that informs the best choice. Your responses will be aggregated for analysis, and your specific responses will not be shared.

Before continuing with this educational activity, please take a moment to answer the following question.

How many people with lung cancer do you provide care for in a typical month?

A.
1-4
B.
5-10
C.
11-15
D.
16-20
E.
> 20
F.
Not applicable

A 62-year-old man with stage IIIB borderline-resectable non-small-cell lung cancer (NSCLC) asks whether an initial 2 cycles of chemotherapy plus durvalumab will increase his chance of undergoing surgery with improved outcomes and if this approach is safe.

Based on MDT-BRIDGE data presented at ESMO 2025, how would you answer his question?

A.
This approach may help convert borderline cases to resectable disease, and safety was consistent with known profiles
B.
Induction therapy guarantees a pathologic complete resection in all responders, so surgery is always the next step
C.
Adding immunotherapy before surgery significantly increases postoperative complications and should be avoided
D.
Two cycles of chemoimmunotherapy rarely change surgical eligibility, so chemoradiation remains the preferred option

A 58-year-old woman with newly diagnosed metastatic EGFR-mutated NSCLC (exon 19 deletion) presents for first-line therapy. She has asymptomatic brain metastases and mild anemia but is otherwise fit for systemic treatment. She asks whether adding platinum-based chemotherapy to osimertinib would meaningfully improve her outcomes.

Based on the FLAURA2 survival data and subgroup analyses presented at ESMO 2025, which treatment approach is most appropriate to recommend?

A.
Osimertinib alone, because patients with brain metastases do not gain meaningful overall survival (OS) benefit from adding chemotherapy
B.
Osimertinib plus chemotherapy, because OS benefit was consistent across prognostic subgroups including those with central nervous system (CNS) metastases
C.
Osimertinib alone, because combination therapy only benefits patients with undetectable EGFR ctDNA at baseline
D.
Osimertinib plus chemotherapy, because combination therapy selectively benefits patients with exon 19 deletions but not exon 21 L858R mutations

Patients with previously untreated advanced NSCLC adenocarcinoma and which of the following biomarkers identified by next-generation sequencing would be candidates for treatment with either sevabertinib or zongertinib in ongoing phase III trials?

A.
EGFR exon 20 mutations
B.
HER2 TKD mutations
C.
KRAS G12D mutations
D.
MET skipping mutations

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Key Studies in Lung Cancer: Independent Conference Coverage of ESMO 2025

Luis Paz-Ares, MD, PhD

David Planchard, MD, PhD

Activity

Introduction

How many people with lung cancer do you provide care for in a typical month?

Patients with previously untreated advanced NSCLC adenocarcinoma and which of the following biomarkers identified by next-generation sequencing would be candidates for treatment with either sevabertinib or zongertinib in ongoing phase III trials?