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To Switch or Not to Switch? That is the ART Question!

Clinical Thought

There are many antiretroviral therapy (ART) regimens for HIV that are highly effective, convenient, safe, and well-tolerated, achieving virologic suppression for nearly all people living with HIV. Nevertheless, switching to a more contemporary ART regimen may still be desirable for some people with virologic suppression. Here, I introduce you to a range of common reasons for switching a suppressive ART regimen and some of the available options for each case.

Released: October 07, 2026

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Provided by Clinical Care Options, LLC dba Decera Clinical Education

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Supporters

This activity is supported through an independent educational grant from Merck & Co., Inc., Rahway, NJ, USA.

Merck & Co., Inc., Rahway, NJ, USA

Target Audience

This activity is intended for physicians, pharmacists, registered nurses, and other healthcare professionals who provide care for people living with HIV.

Learning Objectives

Upon completion of this activity, participants should be able to:

  • Navigate clinical encounters to identify opportunities to optimize ART regimens in virologically suppressed patients

  • Effectively switch ART regimens in virologically suppressed patients to optimize long-term clinical outcomes

  • Evaluate how newly developed and emerging antiretroviral agents could expand the range of options for tailoring an optimal regimen to each individual

Financial Disclosures

Primary Author

Daniel R. Kuritzkes, MD: consultant/advisor/speaker: AbbVie, Gilead, GSK, Janssen, Merck, ViiV; research: ViiV; other financial or material support: Gilead, Janssen.