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Novel Schizophrenia Treatments

CE / CME

Strategic Steps in Schizophrenia: Mastering Modern Muscarinic Management

Psychologists: 0.50 APA CE Credit

Social Workers: 0.50 ASWB ACE CE Credit

Physician Assistants/Physician Associates: 0.50 AAPA Category 1 CME credit

Nurse Practitioners/Nurses: 0.50 Nursing contact hour

Pharmacists: 0.50 contact hour (0.05 CEUs)

Physicians: maximum of 0.50 AMA PRA Category 1 Credit

Released: July 24, 2025

Expiration: July 23, 2026

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Andrew has begun his transition from haloperidol to xanomeline/trospium. He was previously prescribed benztropine to counteract haloperidol-induced extrapyramidal symptoms (EPS). The healthcare professional must now decide how to manage both haloperidol and benztropine as Andrew initiates treatment with xanomeline/trospium, which has a distinct mechanism of action involving muscarinic receptor agonism and may interact unfavorably with anticholinergic agents, such as benztropine.

How should haloperidol and benztropine be managed during the transition to xanomeline/trospium?