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Genetics in pediatric SNHL 1

CE / CME

Optimizing Genetic Evaluation in Pediatric Sensorineural Hearing Loss: A Practical Guide for Hearing Specialists

Physician Assistants/Physician Associates: 0.50 AAPA Category 1 CME credit

Physicians: maximum of 0.50 AMA PRA Category 1 Credit

Nurse Practitioners/Nurses: 0.50 Nursing contact hour

Released: July 30, 2026

Expiration: July 29, 2027

Activity

Progress
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Course Completed

References

  1. Carlson RJ, Walsh T, Mandell JB, et al. Association of genetic diagnoses for childhood-onset hearing loss with cochlear implant outcomes. JAMA Otolaryngol Head Neck Surg. 2023;149:212-222.
  2. Shearer AE. Genetic testing for pediatric sensorineural hearing loss in the era of gene therapy. Curr Opin Otolaryngol Head Neck Surg. 2024;32:352-356.
  3. Azaiez H, Thorpe RK, Odell AM, et al. OTOF-related hearing loss. ncbi.nlm.nih.gov/books/NBK1251/pdf/Bookshelf_NBK1251.pdf. Accessed July 27, 2026.
  4. Li MM, Tayoun AA, DiStefano M, et al; ACMG Professional Practice and Guidelines Committee. Clinical evaluation and etiologic diagnosis of hearing loss: a clinical practice resource of the American College of Medical Genetics and Genomics (ACMG). Genet Med. 2022;24:1392-1406.
  5. Manrique M, Ramos Á, de Paula Vernetta C, et al. Guideline on cochlear implants. Acta Otorrinolaringol Esp (Engl Ed). 2019;70:47-54.
  6. American Academy of Audiology. Clinical practice guideline: cochlear implants. audiology.org/practice-guideline/clinical-practice-guideline-cochlear-implants/. Accessed July 27, 2026.
  7. Usami SI, Nishio SY, Moteki H, et al. Cochlear implantation from the perspective of genetic background. Anat Rec (Hoboken). 2020;303:563-593.
  8. Wu CC. Application of genetic information to cochlear implantation in clinical practice. J Audiol Otol. 2024;28:93-99.
  9. Zheng D, Liu X. Cochlear implantation outcomes in patients with OTOF mutations. Front Neurosci. 2020;14:447.
  10. Shearer AE, Hildebrand MS, Odell AM, et al. Genetic hearing loss overview. ncbi.nlm.nih.gov/books/NBK1434/pdf/Bookshelf_NBK1434.pdf. Accessed July 27, 2026.
  11. Smith RJH, Azaiez H, Odell AM. SLC26A4-related sensorineural hearing loss. ncbi.nlm.nih.gov/books/NBK1467/pdf/Bookshelf_NBK1467.pdf. Accessed July 27, 2026.
  12. NIHR Innovation Observatory. AK-OTOF for treating sensorineural hearing loss. io.nihr.ac.uk/techbriefings/ak-otof-for-treating-sensorineural-hearing-loss/. Accessed July 27, 2026.
  13. FDA. FDA approves first-ever gene therapy for treatment of genetic hearing loss under national priority voucher program. fda.gov/news-events/press-announcements/fda-approves-first-ever-gene-therapy-treatment-genetic-hearing-loss-under-national-priority-voucher. Accessed July 27, 2026.
  14. Lunsotogene parvec-cwha [prescribing information]. Tarrytown, NY: Regeneron Pharmaceuticals, Inc.; 2026.
  15. Fan X, Gao Z, Zhong J, et al. International expert consensus on gene therapy for hereditary hearing loss: based on clinical trials. Med. 2026;7:100886.
  16. FDA. Understanding FDA terms for possible new therapies to prevent and treat diseases. fda.gov/consumers/consumer-updates/understanding-fda-terms-possible-new-therapies-prevent-and-treat-diseases. Accessed July 27, 2026.
  17. FDA. Expanded access. fda.gov/news-events/public-health-focus/expanded-access#. Accessed July 27, 2026.
  18. Heynemann S, Lipworth W, McLachlan SA, et al. Therapeutic misunderstandings in modern research. Bioethics. 2024;38:138-152.
  19. Perry T. Evaluating the media as a source of drug therapy information. Ther Letter. 2007:67.
  20. Porcar-Gozalbo N, López-Zamora M, Valles-González B, et al. Impact of hearing loss type on linguistic development in children: a cross-sectional study. Audiol Res. 2024;14:1014-1027.
  21. Chen MM, Oghalai JS. Diagnosis and management of congenital sensorineural hearing loss. Curr Treat Options Pediatr. 2016;2:256-265.