Interactive Decision Support Tool - Expert Guidance for the Selection of Systemic Agents in Myelofibrosis

Expert Guidance for the Selection of Systemic Agents in Myelofibrosis

Released: October 30, 2026

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About This Tool and Disclaimer

Decera Clinical Education is grateful to John Mascarenhas, MD; Abdulraheem Yacoub, MD; Brady L. Stein, MD, MHS; Kristen Pettit, MD; and Raajit Rampal, MD, PhD, who provided expert guidance and support in developing this Interactive Decision Support Tool.

The tool was developed in September and October 2026.

Recommendations reflect individual faculty opinions for the scenarios presented and may differ from one another, guideline recommendations, or FDA-approved labeling.

The goal is to help healthcare professionals evaluate management options for adults with chronic-phase primary MF or post–polycythemia vera (PV)/post–essential thrombocythemia (ET) MF. The tool addresses selected common scenarios and does not replace individualized clinical assessment.

Depending on the pathway, the questions address blast percentage, prognostic risk, transplant candidacy and preferences, symptoms or splenomegaly, elevated blood counts, prior JAK inhibitor therapy, platelet count, anemia/transfusion status, the reason for a treatment change, and serum erythropoietin (EPO).

Other factors that may affect treatment include comorbidities, performance status, renal and hepatic function, bleeding and thrombotic risk, infection history, concurrent medications, prior treatment duration and dose, molecular/cytogenetic findings, treatment access, and patient goals.

Related learning resources: online modules by Abdulraheem Yacoub, MD, and Sara Leidy, PharmD, BCOP, and a patient toolkit for navigating MF.

Access to and use of the Interactive Decision Support Tool titled “Expert Guidance for Systemic Therapy in Myelofibrosis” are subject to the following terms and conditions.

Please read these terms carefully.

This tool educates healthcare professionals about management options for patients with MF. The recommendations reflect the individual expert guidance of John Mascarenhas, MD; Abdulraheem Yacoub, MD; Brady L. Stein, MD, MHS; Kristen Pettit, MD; and Raajit Rampal, MD, PhD. They do not establish a single preferred regimen or a panel consensus.

Materials published by Decera Clinical Education reflect the views of the authors or reviewers, rather than necessarily those of the educational provider or grant supporters. The activity may discuss uses or doses that are not approved by the FDA. Healthcare professionals should review the full current prescribing information, available evidence, and patient-specific factors before treatment.

Although this tool has been developed from sources believed to be reliable, no warranty, expressed or implied, is made regarding the accuracy, adequacy, completeness, legality, reliability, or usefulness of the information, individually or in aggregate. Decera Clinical Education provides this information on an as-is basis. All warranties, including merchantability, fitness for a particular purpose, freedom from computer viruses, and noninfringement of proprietary rights, are disclaimed.

Any trademarks are the property of their respective companies.

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