Faculty

Erika Hamilton, MD, FASCO

Chief Development Officer, Late Phase
Director, Breast Cancer Research Program
Sarah Cannon Research Institute (SCRI)
Nashville, Tennessee

Otto Metzger, MD

Assistant Professor of Medicine
Harvard Medical School
Attending Physician
Department of Medical Oncology
Dana-Farber Cancer Institute
Associate Medical Director
International Business Initiatives
Executive Officer
Alliance Foundation Trials
Boston, Massachusetts

Provided by

Provided by Clinical Care Options, LLC dba Decera Clinical Education

Supporters

Supported by an educational grant from Pfizer Inc.

Pfizer Inc.

Target Audience

This activity is intended for community medical oncologists, nurse practitioners, physician assistants, nurses, pharmacists, and other healthcare professionals who care for patients with breast cancer.

Learning Objectives

Upon completion of this activity, participants should be able to:

Educate patients on the clinical role and risk–benefit profile of first-line maintenance therapy for HER2-positive MBC
Evaluate the potential of novel combinations to optimize patient outcomes in the first-line maintenance setting for HER2-positive MBC using the latest evidence
Recommend the optimal first-line maintenance therapy for each eligible patient with HER2-positive MBC based on expert recommendations, evidence, HR status, and patient goals
Implement evidence-based multidisciplinary strategies to manage toxicities related to novel first-line maintenance therapies for HER2-positive MBC

Financial Disclosures

Primary Author

Erika Hamilton, MD, FASCO: researcher (paid to institution): AbbVie, Accutar Biotechnology, Artios, Arvinas, AstraZeneca, AtlasMedx, BeiGene, BeOne, Bicycle, Biohaven, BioNTech, Compugen, Cullinan, Daiichi Sankyo, Dantari, Day One Biopharmaceuticals, Duality Biologics, Ellipses, Elucida Oncology, Exelixis, FujiFilm, Genmab, Gilead, H3 Biomedicine, Iambic Therapeutics, Immunogen, Inspirna, InventisBio, Jacobio, Jazz, K-Group Beta, Kind, Lilly, Loxo Oncology, Mabspace, Mabwell, Marengo, MediLink, Merck, Mersana, Novartis, Olema, Orinove, Orum, Pfizer, Pionyr, Prelude, Profound Bio, Regeneron, Relay, Rgenix, Roche/Genentech, SeaGen, Shattuck Labs, Simcha, Stemline, Sutro, Systimmune, Taiho, Tesaro, TheRas, Treadwell, Verastem, Xadcera, Zymeworks; consultant/advisor (paid to institution): Arvinas, AstraZeneca, BeOne, BioNTech, Boehringer Ingelheim, Boundless Bio, Bristol Myers Squibb, Circle, Daiichi Sankyo, Gilead, Halda, Incyclix, IQVIA, Janssen, Jazz, Jefferies, Johnson & Johnson, Lilly, Mersana, Novartis, Pfizer, Precede, Pyxis Oncology, Roche/Genentech, Samsung Bioepis, Shorla, Stemline, Tempus.

Otto Metzger, MD: advisor: AstraZeneca, Daichii Sankyo, Jazz, Pfizer; researcher: Pfizer.

Additional Disclosures

Generative artificial intelligence (AI) tools were used for drafting educational content, revising or refining educational content, and drafting assessment question(s) and/or rationale(s). All AI-assisted content underwent human review, editing, and validation by qualified faculty and accredited education staff to ensure scientific accuracy, balance, and compliance with the ACCME Standards for Integrity and Independence in Accredited Continuing Education.

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Expert Answers on First-line Maintenance Therapy for HER2-Positive Metastatic Breast Cancer

Clinical Thought