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Barriers to CAR T Cell Therapy

CE / CME

From Evidence to Practice—Barriers to Access and Manufacturing Delays in CAR T-Cell Therapy

ABIM MOC: maximum of 0.50 Medical Knowledge MOC point

Physicians: Maximum of 0.50 AMA PRA Category 1 Credit

Released: December 09, 2025

Expiration: June 08, 2026

Activity

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Introduction

In this module, Noopur Raje, MD, explores the logistical, clinical, and socioeconomic barriers to access and timely administration of CAR T-cell therapy in MM. Challenges related to manufacturing delays, patient eligibility, and coordination between treatment centers and community oncologists are discussed, and early referral and optimal bridging strategies to improve outcomes are highlighted.

The key points discussed in this module are illustrated with thumbnails from the accompanying downloadable PowerPoint slideset, which can be found here or downloaded by clicking on any of the slide thumbnails in the module alongside the expert commentary.

Please note that Decera Clinical Education plans to measure the educational impact of this activity. Some questions are asked twice: once at the beginning of the activity, and once again after the discussion that informs the best choice. Your responses will be aggregated for analysis, and your individual responses will not be shared. Thank you in advance for helping us assess the impact of this education.

Before continuing with this educational activity, please take a moment to answer the following questions.

A 63-year-old woman with relapsed/refractory (R/R) multiple myeloma (MM) is referred for CAR T-cell therapy. Her T-cells have been successfully collected, and she is now awaiting manufacturing and infusion. She has a high disease burden but remains asymptomatic.

Which of the following best describes the rationale for using bridging therapy in this patient?

How many people with MM do you provide care for in a typical month?

For those who practice in academic or community settings, please indicate your practice setting: