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ASCENT-04: Safety Analysis of Phase III Trial of Pembrolizumab With Sacituzumab Govitecan or Chemotherapy in Previously Untreated PD-L1+ Metastatic TNBC

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Slideset

In the phase III ASCENT-04 trial, treatment with sacituzumab govitecan with pembrolizumab in patients with previously untreated PD-L1–positive metastatic TNBC showed a manageable safety profile consistent with previous experience in patients with advanced breast cancer.

Released: December 16, 2025

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Provided by Clinical Care Options, LLC dba Decera Clinical Education

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Supporters

Supported by educational grants from AstraZeneca, Daiichi Sankyo, Inc, Genentech, a member of the Roche Group, Gilead Sciences, Inc., Lilly, Novartis Pharmaceuticals Corporation, and Stemline Therapeutics, Inc.

AstraZeneca

Daiichi Sankyo, Inc.

Genentech, a member of the Roche Group

Gilead Sciences, Inc.

Lilly

Novartis Pharmaceuticals Corporation

Stemline Therapeutics, Inc.

Target Audience

This activity is intended for oncologists and other healthcare professionals who care for patients with breast cancer.

Learning Objectives

Upon completion of this activity, participants should be able to:

  • Identify subpopulations of patients with breast cancer most likely to benefit from a specific treatment plan based on predictive biomarkers

  • Apply recently presented data to clinical practice to expand treatment options and improve outcomes for patients with breast cancer
  • Evaluate new data on novel agents and therapeutic approaches for patients with breast cancer