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Evaluating, Diagnosing, and Managing IgG4-RD in Nephrology

Clinical Thought

IgG4-related disease (IgG4-RD) is a systemic immune-mediated condition that can affect the kidneys and other organs, potentially leading to progressive inflammation, fibrosis, and irreversible organ damage. Diagnosing and managing IgG4-RD requires a systematic and multidisciplinary approach to patient care. Learn how IgG4-RD generally presents in nephrology, the importance of ruling out key mimicking diseases and assessing multiorgan involvement, as well as evidence-based treatment strategies to prevent relapse and irreversible organ damage.

Released: October 18, 2026

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Provided by Clinical Care Options, LLC dba Decera Clinical Education

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Supporters

This activity is supported by educational funding provided by Amgen.

Amgen

Target Audience

This program is intended for gastroenterologists, rheumatologists, nephrologists, primary care physicians, NPs, and PAs caring for patients with IgG4-RD.

Learning Objectives

Upon completion of this activity, participants should be able to:

  • Identify the multisystem clinical manifestations and evidence-based classification criteria used in the diagnosis of IgG4-RD

  • Develop multidisciplinary management strategies for IgG4-RD that support coordinated care, relapse monitoring, and glucocorticoid-sparing approaches

Financial Disclosures

Primary Author

Jai Radhakrishnan, MD, MS: consultant/advisor/speaker: Amgen, BeOne, Biogen, Calliditas, GSK, Novartis, Sanofi Genzyme, Travere, Vera; researcher: Mineralys, Vertex.

Additional Disclosures

Generative artificial intelligence (AI) tools were used for revising or refining educational content.

AI-assisted content was reviewed by qualified faculty and accredited education staff, with independent verification of references and clinical claims, to ensure scientific accuracy, balance, independence, and freedom from bias or commercial influence.