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Symptom Management for PBC
Setting Our Sights on Symptom Management: Raising the Bar in PBC Management Podcast

Released: December 11, 2025

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Historically, key symptoms of primary biliary cholangitis (PBC), such as pruritus and fatigue, have been understudied and undertreated. Listen now to learn how symptom management should be considered independently of PBC management, and how new therapeutic agents can help.

Topics covered include:

  • Mechanisms of pruritus and fatigue in PBC
  • Nonpharmacologic treatment options
  • An overview of clinical trial data supporting second-line agents for symptom management:
    • Bezafibrate
    • Elafibranor
    • Seladelpar
  • Investigational agents:
    • Volixibat
    • Linerixibat
    • Setanaxib

This episode is the third of 3 recap podcasts, featuring audio from our live satellite symposium, Raising the Bar: Innovations in PBC Care. For the full on-demand webcast of this satellite symposium, and to download the accompanying slides, visit the program page for this episode: https://bit.ly/44ZJ5os