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Each to Their Own: Matching 2DR and 3DR to Patient Profiles

Clinical Thought

Starting antiretroviral therapy (ART) as soon as possible, even on the same day as HIV diagnosis, is an important standard in HIV care, supported by the World Health Organization and other guidelines. In this rapid test-and-treat context, is there a role for 2-drug regimens among the spectrum of ART choices?

Released: October 19, 2026

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Provided by Clinical Care Options, LLC dba Decera Clinical Education

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Supporters

This activity is supported by an educational grant from ViiV Healthcare.

ViiV Healthcare

Target Audience

This program is intended for physicians (including HIV/infectious disease specialists, primary care physicians, and internists), nurse practitioners, physician assistants, pharmacists, and other healthcare professionals involved in the initiation of antiretroviral therapy in adults living with HIV.

Learning Objectives

Upon completion of this activity, participants should be able to:

  • Integrate the clinical evidence, including results from VOGUE and other key trials and real-world studies, to make informed, evidence-based decisions about the comparative merits of 2DR and 3DR for ART initiation

  • Apply evidence-based clinical frameworks to select between 2DR and 3DR across a range of commonly encountered first-line ART scenarios, and communicate the rationale for 2DR confidently in shared decision-making conversations with people living with HIV

Financial Disclosures

Primary Author

Jade Ghosn, MD, PhD, has no relevant financial relationships to disclose.

Additional Disclosures

Generative artificial intelligence (AI) tools were used for revising or refining educational content. All AI-assisted content underwent human review, editing, and validation by qualified faculty and accredited education staff to ensure scientific accuracy, balance, and compliance with the ACCME Standards for Integrity and Independence in Accredited Continuing Education.