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When Injection Succeeds Where the Pill Fails: Reframing Adherence Through Long-Acting ART

Clinical Thought

The most effective antiretroviral (ART) regimen is not necessarily the one with the highest genetic barrier or the fewest resistance concerns. It may be the regimen that one can reliably receive. Read how, for some people living with HIV who struggle with oral ART, long-acting injectable ART can transform adherence from the central obstacle to sustained viral suppression into a manageable component of care. 

Released: August 10, 2026

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Provided by

Provided by Clinical Care Options, LLC dba Decera Clinical Education

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Supporters

This activity is supported by an educational grant from ViiV Healthcare.

ViiV Healthcare

Target Audience

This activity is intended for physicians, registered nurses, pharmacists, and other healthcare professionals who provide care for people living with HIV who experience adherence challenges.

Learning Objectives

Upon completion of this activity, participants should be able to:

  • Identify appropriate candidates for LA ART among people experiencing persistent viremia or significant structural, psychosocial, or mental health–related barriers that make daily oral adherence difficult or unsustainable

  • Apply best practice strategies for the initiation and sustained use of LA ART in people facing adherence challenges, including strategies for maintaining continuity of care

Financial Disclosures

Primary Author

Monica Gandhi, MD, MPH, has no relevant financial relationships to disclose.

Additional Disclosures

Generative artificial intelligence (AI) tools were used for drafting educational content. All AI-assisted content underwent human review, editing, and validation by qualified faculty and accredited education staff to ensure scientific accuracy, balance, and compliance with the ACCME Standards for Integrity and Independence in Accredited Continuing Education.