Ask AI
See Activity Collection
ProCE Banner Activity

Enough is Enough: Avoiding Overtreatment in ART

Clinical Thought

Years of evidence—and recent changes to the DHHS guidelines—show that a 2-drug regimen can be just as good as a 3-drug regimen for initial ART. So does a reflexive preference for 3-drug ART reflect contemporary evidence or simply decades of clinical habit?

Released: October 19, 2026

Review Activity

Share

Faculty

Pedro Cahn

Pedro Cahn, MD, PhD

Scientific Director, Fundacion Huesped
Buenos Aires, Argentina

Provided by

Provided by Clinical Care Options, LLC dba Decera Clinical Education

ProCE Banner

Supporters

This activity is supported by an educational grant from ViiV Healthcare.

ViiV Healthcare

Target Audience

This program is intended for physicians (including HIV/infectious disease specialists, primary care physicians, and internists), nurse practitioners, physician assistants, pharmacists, and other healthcare professionals involved in the initiation of antiretroviral therapy in adults living with HIV.

Learning Objectives

Upon completion of this activity, participants should be able to:

  • Integrate the clinical evidence, including results from VOGUE and other key trials and real-world studies, to make informed, evidence-based decisions about the comparative merits of 2DR and 3DR for ART initiation

  • Apply evidence-based clinical frameworks to select between 2DR and 3DR across a range of commonly encountered first-line ART scenarios, and communicate the rationale for 2DR confidently in shared decision-making conversations with people living with HIV

Financial Disclosures

Primary Author

Pedro Cahn, MD, PhD: consultant/advisor/speaker: ViiV; researcher: Gilead, MSD.

Additional Disclosures

Generative artificial intelligence (AI) tools were used for revising or refining educational content. All AI-assisted content underwent human review, editing, and validation by qualified faculty and accredited education staff to ensure scientific accuracy, balance, and compliance with the ACCME Standards for Integrity and Independence in Accredited Continuing Education.