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Most likely, most people living with HIV in your practice are virologically suppressed and doing well on their current antiretroviral therapy (ART), which raises the questions of when to change an ART regimen that is working and why. The case for switching rests on subtle differences in tolerability, metabolic effects, drug–drug interactions, resistance barrier, and mode of administration that, when taken together, can be decisive for a given individual. Download these slides to learn more about how to navigate commonly encountered ART switch scenarios.