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PV Case Challenge

CME

Interactive Case Challenge: Diagnosing and Managing a Patient With Polycythemia Vera

Physicians: Maximum of 0.50 AMA PRA Category 1 Credit

Released: April 14, 2026

Expiration: October 13, 2026

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For those who practice in academic or community settings, please indicate your practice setting:

How many people with myeloproliferative neoplasms do you provide care for in a typical month?

A male patient with which of the following findings on workup does not require a bone marrow biopsy to establish a diagnosis of polycythemia vera (PV)?

A 64-year-old man presents to the emergency department with chest pain, leading to the diagnosis of myocardial infarction. He has a history of arterial hypertension and deep vein thrombosis (4 years ago). On clinical examination, he has palpable splenomegaly (2 cm). His blood counts are as follows: Hgb 20 g/dL, Hct 61.7%, white blood cell (WBC) 12.8 x 109/L, and platelets 750 x 109/L. He is referred for exploration of his elevated blood counts. Based on current findings, you suspect that the patient may have PV.

Which of the following noninvasive diagnostic tests would you propose for this patient?