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Evaluating, Diagnosing, and Managing IgG4-RD in Gastroenterology

Clinical Thought

IgG4-related disease (IgG4-RD) is a rare, chronic immune-mediated condition that can affect multiple organs and lead to progressive inflammation, fibrosis, and irreversible organ damage. Diagnosing and managing IgG4-RD requires a systematic and multidisciplinary approach to patient care. Learn how IgG4-RD generally presents in gastroenterology, the importance of recognizing multiorgan involvement and ruling out key mimicking diseases, and evidence-based treatment strategies to achieve disease control, prevent relapse, and reduce the risk of irreversible organ damage.

Released: October 14, 2026

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Provided by

Provided by Clinical Care Options, LLC dba Decera Clinical Education.

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Supporters

This activity is supported by educational funding provided by Amgen.

Amgen

Target Audience

This program is intended for gastroenterologists, rheumatologists, nephrologists, primary care physicians, NPs, and PAs caring for patients with IgG4-RD.

Learning Objectives

Upon completion of this activity, participants should be able to:

  • Identify the multisystem clinical manifestations and evidence-based classification criteria used in the diagnosis of IgG4-RD

  • Develop multidisciplinary management strategies for IgG4-RD that support coordinated care, relapse monitoring, and glucocorticoid-sparing approaches

Financial Disclosures

Primary Author

Yasmin G. Hernandez-Barco, MD: consultant/advisor/speaker: Amgen, Nestle Health Science, Sanofi, Zenas.

Additional Disclosures

Generative artificial intelligence (AI) tools were used for revising or refining educational content. All AI-assisted content underwent human review, editing, and validation by qualified faculty and accredited education staff to ensure scientific accuracy, balance, and compliance with the ACCME Standards for Integrity and Independence in Accredited Continuing Education.