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Evaluating, Diagnosing, and Managing IgG4-RD in Rheumatology

Clinical Thought

IgG4-related disease (IgG4-RD) is a rare, multisystem immune-mediated condition that can cause progressive inflammation, fibrosis, and irreversible organ damage. Diagnosing and managing IgG4-RD requires a systematic and multidisciplinary approach to patient care. Learn how IgG4-RD generally presents in rheumatology, the importance of ruling out key mimicking diseases and assessing multiorgan involvement, and evidence-based treatment strategies to prevent relapse and irreversible organ damage.

Released: October 14, 2026

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Provided by

Provided by Clinical Care Options, LLC dba Decera Clinical Education.

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Supporters

This activity is supported by educational funding provided by Amgen.

Amgen

Target Audience

This program is intended for gastroenterologists, rheumatologists, nephrologists, primary care physicians, NPs, and PAs caring for patients with IgG4-RD.

Learning Objectives

Upon completion of this activity, participants should be able to:

  • Identify the multisystem clinical manifestations and evidence-based classification criteria used in the diagnosis of IgG4-RD

  • Develop multidisciplinary management strategies for IgG4-RD that support coordinated care, relapse monitoring, and glucocorticoid-sparing approaches

Financial Disclosures

Primary Author

Guy Katz, MD, MS: consultant/advisor/speaker: Acepodia, Amgen, Zenas; researcher: Amgen, Sana; independent contractor: Sanofi.

Additional Disclosures

Generative artificial intelligence (AI) tools were used for revising or refining educational content. All AI-assisted content underwent human review, editing, and validation by qualified faculty and accredited education staff to ensure scientific accuracy, balance, and compliance with the ACCME Standards for Integrity and Independence in Accredited Continuing Education.