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Unlocking Recovery in Treatment-Resistant Depression: Patient-Specific, Real-world Application for APPs

Slideset

Many patients with major depression do not respond adequately to their first-line or even second-line trials of antidepressants, leading to treatment-resistant depression (TRD), a form associated with significantly greater symptom burden and functional impairment. Learn effective management of TRD with a personalized approach that integrates patient goals, shared decision-making, and a nuanced understanding of available pharmacologic and nonpharmacologic options.

Released: May 05, 2026

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Provided by Clinical Care Options, LLC dba Decera Clinical Education

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Target Audience

This activity is intended for psychiatric and primary care APPs who treat patients with TRD, including nurse practitioners, physican associates, and nurses.

Learning Objectives

Upon completion of this activity, participants should be able to:

  • Employ evidence-based strategies to measure response to treatment in MDD and promote earlier identification of TRD

  • Apply evidence on safety, efficacy, and pharmacologic profiles of TRD treatments to clinical decision-making

  • Integrate share decision-making into the construction of personalized treatment plans for patients with TRD