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Beyond Hot Flashes: Recognizing and Managing Mood Disorders During Perimenopause

Slideset

Perimenopause is associated with a 2- to 4-fold increased risk of depression compared with other life periods, highlighting the importance of recognizing mood symptoms during this hormonal transition. This downloadable slideset examines hormonal fluctuations, vasomotor and sleep symptoms, and patient-specific risk factors that may contribute to perimenopausal depression. It also reviews current approaches to management, including antidepressants, hormone replacement therapy, nonhormonal options, and lifestyle strategies.

Released: September 21, 2026

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Provided by Clinical Care Options, LLC dba Decera Clinical Education

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Target Audience

This activity is intended for physicians, nurse practitioners, registered nurses, pharmacists, physician associates, social workers, and psychologists engaged in the care of women with mood disorders.

Learning Objectives

Upon completion of this activity, participants should be able to:

  • Explore the hormonal changes during perimenopause and menopause

  • Identify the patient-centric key factors that contribute to an increased risk of depression during perimenopause

  • Discuss the current guidelines and treatment options for addressing depressive symptoms for patients with perimenopausal depression