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Breaking the Therapeutic Ceiling in Schizophrenia Care: What’s New?

Slideset

Schizophrenia treatment is evolving beyond traditional dopamine D2 receptor blockade. This slideset reviews updated dopamine pathway concepts, muscarinic M1/M4 agonism, clinical evidence for xanomeline/trospium, practical administration and monitoring considerations, and emerging therapeutic strategies in schizophrenia care.

Released: May 06, 2026

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Provided by Clinical Care Options, LLC dba Decera Clinical Education

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Supporters

Supported by an educational grant from Bristol Myers Squibb. 

Bristol Myers Squibb

Target Audience

This activity is intended for healthcare professionals caring for patients with schizophrenia including psychiatrists, physicians, nurse practitioners, physician associates, registered nurses, pharmacists, social workers, and psychologists.

Learning Objectives

Upon completion of this activity, participants should be able to:

  • Differentiate dopaminergic and muscarinic mechanisms of actions of novel therapies, and explain the clinical utility to address unmet needs of patients with schizophrenia

  • Evaluate emerging clinical evidence supporting novel therapies in schizophrenia, with attention to efficacy signals, safety considerations, and current limitations of the data

  • Design strategies to integrate novel therapeutic options into treatment plans for patients with schizophrenia while counseling them on optimal administration and side effect management