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Beyond Dopamine: Muscarinic Receptor Agonism as a New Mechanistic Frontier in Schizophrenia Care

Clinical Thought

Muscarinic receptor agonism represents a novel approach to schizophrenia treatment that offers an alternative to traditional antipsychotic therapies. Learn more about the clinical implications of muscarinic receptor agonism, including its potential role in individualized treatment selection, emerging evidence regarding transitions from existing antipsychotics, and considerations for concomitant medication use. 

Released: October 21, 2026

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Provided by Clinical Care Options, LLC dba Decera Clinical Education

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Supporters

Supported by an educational grant from Bristol Myers Squibb. 

Bristol Myers Squibb

Target Audience

This program is intended for healthcare professionals caring for patients with schizophrenia including psychiatrists, physicians, nurse practitioners, physician associates, registered nurses, pharmacists, social workers, and psychologists.

Learning Objectives

Upon completion of this activity, participants should be able to:

  • Explain the clinical utility of novel antipsychotics to address unmet needs of current schizophrenia treatments

  • Define the distinctive mechanisms of action and pharmacokinetic characteristics of novel and emerging therapeutic agents for schizophrenia that extend beyond traditional antidopaminergic approaches

  • Integrate novel therapeutic options into treatment plans for appropriate patients with schizophrenia based on current clinical evidence

  • Counsel patients on optimal administration and side effect management for schizophrenia therapies to maximize adherence

  • Design strategies to holistically assess the range symptoms in schizophrenia and the impact of therapy on patient outcomes

Financial Disclosures

Primary Author

Rebecca DePalma, DMSc, PA-C: consultant/advisor/speaker: AbbVie, Bristol Myers Squibb.

Additional Disclosures

Generative artificial intelligence (AI) tools were used for drafting and revising or refining educational content. All AI-assisted content underwent human review, editing, and validation by qualified faculty and accredited education staff to ensure scientific accuracy, balance, and compliance with the ACCME Standards for Integrity and Independence in Accredited Continuing Education.