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Troubleshooting the Tough Bipolar Case: The Who, When, and How of Mixed Features and Anxious Distress

Slideset

This downloadable slideset summarizes the clinical approach to managing bipolar disorder by diving into the complexities of mixed features and anxious distress, including their significant clinical implications for patient health. It also reviews evidence-based treatment strategies, with a focused look at the efficacy of atypical antipsychotics vs the risks of antidepressants, equipping you to create more effective and individualized care plans for these challenging presentations.

Released: December 05, 2025

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Provided by

Provided by Clinical Care Options, LLC dba Decera Clinical Education

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Supporters

Supported by an educational grant from Intra-Cellular Therapies, Inc.

Intra-Cellular Therapies, Inc.

Target Audience

This activity is intended for healthcare professionals caring for patients with bipolar depression, including psychiatrists, nurse practitioners, physician associates, registered nurses, pharmacists, social workers, and psychologists. 

Learning Objectives

Upon completion of this activity, participants should be able to:

  • Recognize bipolar depression by applying diagnostic criteria, including DSM-5-TR specifiers for mixed features and anxious distress, with awareness that mixed features increase the risk of morbidity and mortality

  • Evaluate the latest clinical evidence for treating bipolar depression, particularly when mixed features or anxious distress are present

  • Develop an individualized treatment plan for patients with bipolar depression, including those with mixed features or anxious distress, to help reduce their risk of morbidity and mortality

Disclosure

Primary Author

Joseph F. Goldberg, MD: consultant/advisor/speaker: AbbVie, Alkermes, Alvogen, Axsome, Bristol Myers Squibb, Genomind, Luye, Neumora, Otsuka.