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Reducing Opioid Reliance: Updating Acute Pain Management With Novel Non-Opioid Analgesics

Slideset

Current opioid and non-opioid options for acute pain each carry limitations that can complicate individualized treatment decisions. These downloadable slides provide expert-led, practical considerations for tailoring acute pain management based on pain mechanism, patient characteristics, procedural context, and treatment constraints. Learners will explore multimodal strategies, new options in selective NaV1.8 inhibition, and case-based approaches for integrating established and newer non-opioid options into care for moderate to severe acute pain.

Released: September 09, 2026

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Provided by Clinical Care Options, LLC dba Decera Clinical Education

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Supporters

This activity is supported by an educational grant from Vertex Pharmaceuticals.

Vertex Pharmaceuticals

Target Audience

This activity is intended for healthcare professionals involved in the management of acute pain, including physicians, nurses, physician associates, and those practicing in gynecology, urology, internal medicine, family medicine, emergency medicine, general surgery, plastic surgery and orthopedic surgery.

Learning Objectives

Upon completion of this activity, participants should be able to:

  • Summarize unmet needs related to current opioid-based therapeutic approaches for acute pain management

  • Assess mechanistic underpinnings of pain pathophysiology, including the role of voltage-gated sodium channels NaV1.7, NaV1.8, and NaV1.9 in pain transmission

  • Evaluate the mechanism of action, pharmacologic profiles, efficacy, and safety of approved and key investigational sodium channel inhibitors for acute moderate to severe pain management

  • Apply evidence-based strategies to optimize management of people with acute pain in a way that minimizes safety concerns while preserving quality of life

Additional Disclosures

Generative artificial intelligence (AI) tools were used for revising or refining educational content and drafting assessment question(s) and/or rationale(s). All AI-assisted content underwent human review, editing, and validation by qualified faculty and accredited education staff to ensure scientific accuracy, balance, and compliance with the ACCME Standards for Integrity and Independence in Accredited Continuing Education.