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Mapping TROP-2–Targeted ADCs Into the NSCLC Treatment Landscape

Clinical Thought

Approval of 2 new TROP-2–targeted ADCs in NSCLC is on the horizon, but how should they be sequenced with other ADCs, and should patients be concerned about key toxicities associated with these agents? 

Released: May 02, 2024

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Supported by an educational grant from Gilead Sciences, Inc.

Gilead Sciences, Inc.

Financial Disclosures

Primary Author

Luis Paz-Ares, MD, PhD

Chair of the Department of Medical Oncology
Hospital Universitario 12 de Octubre
Professor of Medicine at Universidad Computense de Madrid
Co-Director at the Spanish National Cancer Research Center (CNIO) and Head of the Lung Cancer Unit
Madrid, Spain

Luis Paz-Ares, MD, PhD: researcher: AstraZeneca, Bristol Myers Squibb, MSD, Pfizer; consultant/advisor/speaker: Amgen, AstraZeneca, Bayer, Bristol Myers Squibb, Daiichi Sankyo, GSK, Janssen, Lilly, Merck, Mirati, MSD, Novartis, Pfizer, Pharmamar, Roche, Sanofi, Servier, Takeda; executive role: Altum Sequencing, Stab Therapeutics.

David Planchard, MD, PhD

Gustave Roussy
Head of Thoracic Group
Department of Medical Oncology
Villejuif, France

David Planchard, MD, PhD: consultant/advisor/speaker: AbbVie, ArriVent, AstraZeneca, Boehringer Ingelheim, Bristol Myers Squibb, Celgene, Daiichi Sankyo, GlaxoSmithKline, Janssen, Lilly, Merck, Mirati, Novartis, Pfizer, Pierre-Fabre, Roche, Seagen, Takeda; researcher (paid to institution): AbbVie, ArriVent, AstraZeneca, Boehringer Ingelheim, Bristol Myers Squibb, Daiichi Sankyo, Janssen, Lilly, Merck, Mirati, Novartis, Novocure, Pfizer, Pierre-Fabre, Roche, Sanofi-Aventis, Taiho, Takeda.

Helena Yu, MD

Research Director
Professor
Thoracic Oncology
Memorial Sloan Kettering Cancer Center
New York, New York

Helena Yu, MD: consultant/advisor/speaker: AstraZeneca, Blossom Hill, Bristol Myers Squibb, Daiichi Sankyo, Janssen, Summit, SystImmune, Taiho.