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OPTIMA: Phase III Noninferiority Trial of Gene Expression–Directed Chemotherapy in Patients With High-Risk ER+/HER2- Early Breast Cancer

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Slideset

The phase III OPTIMA noninferiority trial found that pretreatment 50-gene Prosigna testing in patients with high-risk ER+/HER2- early breast cancer and low risk of recurrence scores effectively identifies patients who are unlikely to benefit from adjuvant chemotherapy.

Released: July 07, 2026

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Provided by

Provided by Clinical Care Options, LLC dba Decera Clinical Education.

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Supporters

This activity is supported by educational grants from Lilly and Stemline Therapeutics, Inc.

Lilly

Stemline Therapeutics, Inc.

Target Audience

This activity is intended for oncologists and other healthcare professionals who care for patients with various forms of breast cancer.

Learning Objectives

Upon completion of this activity, participants should be able to:

  • Integrate cutting-edge data from breast cancer studies at ASCO 2026 and expert guidance to optimize personalized breast cancer care and improve patient outcomes

  • Utilize prognostic and predictive biomarkers to accurately identify breast cancer patients most likely to benefit from specific targeted therapies and treatment strategies

  • Interpret newly released clinical data on novel agents, updated guidelines, and emerging therapeutic approaches for breast cancer to accelerate their effective incorporation into clinical practice