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Clinical Focus in Paroxysmal Nocturnal Hemoglobinuria: New Strategies for Evading the Complement Cascade

Slideset

The downloadable slideset provides an overview of paroxysmal nocturnal hemoglobinuria (PNH). Experts present the pathogenesis and burden of the disease as well as data from clinical trials to demonstrate the evolution of new therapies for PNH.

Released: March 10, 2026

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Provided by Clinical Care Options, LLC dba Decera Clinical Education

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Supporters

Supported by an educational grant from Novartis Pharmaceuticals Corporation.

Novartis Pharmaceuticals Corporation

Target Audience

This educational activity is intended for hematologists and other healthcare professionals who diagnose and care for patients with paroxysmal nocturnal hemoglobinuria.

Learning Objectives

Upon completion of this activity, participants should be able to:

  • Evaluate current recommendations for managing PNH, including challenges to optimal outcomes, potential therapeutic targets in the complement cascade, and evidence for emerging complement-targeted therapies

  • Differentiate the mechanisms of action for conventional and emerging complement-targeted therapies in PNH

  • Select appropriate complement-targeted therapies for treating patients with PNH by analyzing efficacy and safety evidence, indications, disease-related factors, and patient needs and preferences

  • Implement recommended patient-centered strategies to identify and manage complications associated with PNH