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Myelofibrosis: From Disease Biology and Risk Stratification to JAK Inhibitor Selection, Symptom Control, and Individualized Patient Care

Slideset

This slideset reviews the biology and clinical course of myelofibrosis, including JAK-STAT pathway dysregulation, prognostic risk stratification, symptom and cytopenia burden, and the role of molecular and clinical features in treatment planning. Here, an expert examines pivotal and contemporary evidence supporting the use of JAK inhibitors, including ruxolitinib, pacritinib, momelotinib, and fedratinib, with attention to spleen volume reduction, symptom improvement, hematologic considerations, survival outcomes, and agent selection based on platelet count, anemia, transplant eligibility, and other patient-specific factors. The activity also addresses supportive care, quality-of-life burden, health disparities, and the importance of aligning treatment goals with patient preferences, helping learners apply available evidence to individualized management decisions across the myelofibrosis disease spectrum.

Released: August 25, 2026

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Provided by

Provided by Clinical Care Options, LLC dba Decera Clinical Education In partnership with Smart Patients, Inc.

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Supporters

This educational activity is supported by independent medical education grants from GSK, Incyte Corporation, and Sobi.

GSK

Incyte Corporation

Sobi

Partners

Smart Patients, Inc.

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Target Audience

This activity is intended for oncologists, hematologists, nurses, pharmacists, and other healthcare professionals who care for patients with myelofibrosis.

Learning Objectives

Upon completion of this activity, participants should be able to:

  • Plan individualized treatment strategies for patients with MF, considering patient medical and treatment history, available clinical evidence, and expert guidelines

Additional Disclosures

Generative artificial intelligence (AI) tools were used for data analysis or summarization influencing content. All AI-assisted content underwent human review, editing, and validation by qualified faculty and accredited education staff to ensure scientific accuracy, balance, and compliance with the ACCME Standards for Integrity and Independence in Accredited Continuing Education.