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CLL Management: Testing for MRD and BTK Mutations

Clinical Thought

In this commentary, an expert discusses the usefulness and implications of routine testing for minimal residual disease and BTK mutations in the management of chronic lymphocytic leukemia and why understanding BTK inhibitor resistance is critical for improving patient care.

Released: November 05, 2024

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Provided by Clinical Care Options, LLC

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Supported by an educational grant from AstraZeneca

AstraZeneca

Disclosure

Primary Author

Jennifer R. Brown, MD, PhD

Director, CLL Center, and Institute Physician
Dana-Farber Cancer Institute
Worthington and Margaret Collette Professor of Medicine in the field of Hematologic Oncology
Harvard Medical School
Boston, Massachusetts

Jennifer R. Brown, MD, PhD: consultant/advisor/speaker: AbbVie, Acerta/AstraZeneca, Alloplex, BeOne, Bristol Myers Squibb, EcoR1, Galapagos, Genentech/Roche, Grifols Worldwide Operations, InnoCare, Loxo/Lilly, Magnet Biomedicine, Nurix, Pharmacylics; researcher: BeOne, Gilead, iOnctura, Loxo/Lilly, Nagoon; data and safety monitoring board: Grifols.