CE / CME
In this certified on-demand webcast, experts discuss evidence-based approaches to selecting and sequencing first-line and maintenance therapies for HER2-positive metastatic breast cancer from key clinical trials as well as practical considerations inspired by patient cases.
Physician Assistants/Physician Associates: 1.00 AAPA Category 1 CME credit
Pharmacists: 1.00 contact hour (0.1 CEUs)
Physicians: maximum of 1.00 AMA PRA Category 1 Credit™
European Learners: 1.00 EBAC® CE Credit
Nurse Practitioners/Nurses: 1.00 Nursing contact hour
Released: March 31, 2026
Expiration: September 30, 2026
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Provided by Clinical Care Options, LLC dba Decera Clinical Education
Supported by an educational grant from Pfizer Inc.
Pfizer, Inc.
This activity is intended for oncologists, nurse practitioners, physician associates, nurses, pharmacists, and other healthcare professionals who care for patients with breast cancer.
This educational activity aims to improve learners' understanding, knowledge, and competence in optimizing the care of patients with HER2+ MBC with maintenance therapy in the first-line setting.
Upon completion of this activity, participants should be able to:
Describe the role of maintenance therapy in the first line treatment setting for patients with HER2+ MBC and its impact on the therapeutic index, toxicity, treatment de-escalation, and the burden of treatment for patients
Discuss the role of endocrine therapy in the treatment of patients with HER2+/HR+ MBC in the first line setting
Develop and apply individualized treatment plans and multi-drug management strategies in the maintenance setting for patients with MBC
Assess and implement the latest clinical evidence regarding advancements made in the standard of care in the first line setting for patients with HER2+ MBC
Decera Clinical Education requires instructors, planners, managers, and other individuals who are in a position to control the content of this activity to disclose all financial conflicts of interest (COI) they may have with ineligible companies. All relevant COI are thoroughly vetted and mitigated according to Decera Clinical Education policy. Decera Clinical Education is committed to providing its learners with high-quality CME/CE activities and related materials that promote improvements or quality in healthcare and not a specific proprietary business interest of an ineligible company.
The faculty reported the following relevant financial relationships or relationships to products or devices they have with ineligible companies related to the content of this educational activity:
Primary AuthorGiuseppe Curigliano, MD, PhD: consultant/advisor/speaker: AstraZeneca, Daiichi Sankyo, Exact Sciences, Gilead, Lilly, Menarini, Novartis, Pfizer, Roche.
Kevin Kalinsky, MD, MS, FASCO: consultant/advisor/speaker: AstraZeneca, Daiichi Sankyo, Genentech/Roche, Gilead, Mersana, Puma, Seattle Genetics.
The planners and content peer reviewers from Decera Clinical Education do not have any relevant financial relationships to disclose, except Kristi K. Orbaugh, MSN, NP, AOCNP, as noted below:
Kristi K. Orbaugh, MSN, NP, AOCNP: speaker: AstraZeneca, Boehringer Ingelheim, Bristol Myers Squibb, DSI, Exelixis, Lilly, Pfizer, Stemline.
Participation in this self-study activity should be completed in approximately 1 hour. To successfully complete this activity and receive credit, participants must follow these steps during the period from March 31, 2026, through September 30, 2026:
You must receive a test score of at least 65 and respond to all evaluation questions to receive a certificate. After submitting the evaluation, you may access your online certificate by selecting the certificate link on the confirmation page. Records of all CME/CE activities completed can be found on the "My Certificates" page. There are no costs/fees for this activity.
This program has been made available online.
This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. The planners of this activity do not recommend the use of any agent outside of the labeled indications.
The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of the planners. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.
Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient’s conditions and possible contraindications and/or dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.
Joint Accreditation Statement

In support of improving patient care, Clinical Care Options, LLC dba Decera Clinical Education is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.
Physician Continuing Medical Education
Clinical Care Options, LLC dba Decera Clinical Education designates this enduring material for a maximum of 1 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Nursing Continuing Professional Development
The maximum number of hours awarded for this Nursing Continuing Professional Development activity is 1 contact hour.
Continuing Pharmacy Education

Clinical Care Options, LLC dba Decera Clinical Education designates this continuing education activity for 1 contact hour (0.10 CEUs) of the Accreditation Council for Pharmacy Education. Universal Activity Number: JA4008176-0000-26-249-H01-P
Type of Activity: Application
Upon successfully completing the post-test with a score of 65% or better and the activity evaluation form, transcript information will be sent to the NABP CPE Monitor Service within 60 days.
Physician Associate Continuing Medical Education

Clinical Care Options, LLC dba Decera Clinical Education has been authorized by the American Academy of PAs (AAPA) to award AAPA Category 1 CME credit for activities planned in accordance with AAPA CME Criteria. This activity is designated for 1 AAPA Category 1 CME credit. Approval is valid until September 30, 2026. PAs should only claim credit commensurate with the extent of their participation.
EBAC® Accreditation
Clinical Care Options, LLC dba Decera Clinical Education is an EBAC® accredited provider since 2025

This program is accredited by the European Board for Accreditation of Continuing Education for Health Professionals (EBAC®) for 1 hour of effective education time.
EBAC® holds an agreement on mutual recognition of substantive equivalency with the US Accreditation Council for CME (ACCME) and the Royal College of Physicians and Surgeons of Canada, respectively.
Through an agreement between the European Board for Accreditation of Continuing Education for Health Professionals (EBAC®) and the American Medical Association, physicians may convert EBAC® External CME credits to AMA PRA Category 1 Credits™. Information on the process to convert EBAC® credit to AMA credit can be found on the AMA website. Other health care professionals may obtain from the AMA a certificate of having participated in an activity eligible for conversion of credit to AMA PRA Category 1 Credit™.
EBAC® is a member of the International Academy for CPD Accreditation (IACPDA), the World Federation for Medical Education (WFME) CPD Recognition Committee, and a partner member of the International Association of Medical Regulatory Authorities (IAMRA).
IPCE Credit Designation

This activity was planned by and for the healthcare team, and learners will receive 1 Interprofessional Continuing Education (IPCE) credit for learning and change.
CME Passport

The CME credits that physicians earn from this activity will be submitted to ACCME's CME Passport, a free, centralized web application where you can create a personalized account to view, track, and generate transcripts of your reported CME credit. Visit www.cmepassport.org to create your account.