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Applying Emerging B7-H3 ADC Data to Post-Platinum ES-SCLC Decisions

Slideset

The care of patients with extensive-stage (ES) small-cell lung cancer (SCLC) continues to evolve with the release of new clinical evidence. Watch this video to learn more about the current FDA approvals in ES-SCLC, frontline chemoimmunotherapy options in ES-SCLC, the latest evidence on DLL3-directed T-cell engagers in ES-SCLC, available and emerging treatment options after platinum-based therapy, recent clinical data on the use of investigational B7-H3–directed antibody–drug conjugates, such as ifinatamab deruxtecan, risvutatug rezetecan, tambotatug pelitecan, MHB088C, and elfetabart drozuntecan in ES-SCLC, and a key ongoing phase III trials of B7-H3–directed therapies in ES-SCLC.

Released: November 11, 2026

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Provided by

Provided by Clinical Care Options, LLC dba Decera Clinical Education

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Supporters

This activity is supported by educational grants from Daiichi Sankyo, Inc. and Merck Sharp & Dohme LLC.

Daiichi Sankyo, Inc.

Merck Sharp & Dohme LLC

Target Audience

This activity is intended for oncologists, pulmonologists, nurses, pharmacists, physician associates, and other healthcare professionals who care for patients with extensive-stage small-cell lung cancer.

Learning Objectives

Upon completion of this activity, participants should be able to:

  • Differentiate B7-H3–directed ADCs from other available and emerging ES-SCLC strategies, including DLL3-directed T-cell engagement, chemotherapy-based approaches, maintenance strategies, and clinical trials, based on mechanism, evidence strength, toxicity profile, and operational feasibility

  • Apply emerging efficacy and safety data for investigational B7-H3–directed ADCs to patient-specific treatment planning after platinum-based therapy, including considerations related to platinum-free interval, disease tempo, brain metastases, ECOG performance status, pulmonary comorbidity, prior thoracic radiation, marrow reserve, prior therapy, and access to specialized monitoring

  • Implement practical monitoring and management strategies for ADC-associated adverse events, including ILD/pneumonitis, cytopenias, gastrointestinal adverse events, fatigue, and infusion-related considerations

  • Use case-based decision-making to formulate sequencing, referral, and multidisciplinary management strategies for patients with relapsed ES-SCLC