Staying the Course: Pharmacist Best Practices for Managing Adverse Events and Maintaining Therapy in EGFR-Mutated NSCLC : Pre-test

1.

How many people with lung cancer do you provide care for in a typical month?

A. 1-4
B. 5-10
C. 11-15
D. 16-20
E. > 20
F. Not applicable

2.

For those who practice in academic or community settings, please indicate your practice setting:

A. Academic
B. Community
C. Not applicable

3.

After multidisciplinary review, the 73-yr-old patient with metastatic EGFR exon 21 L858R NSCLC starts first-line amivantamab plus lazertinib.

Which pharmacist-led management plan is most appropriate at treatment initiation to help sustain therapy adherence while minimizing toxicity?

A. Reduce lazertinib up front for CrCl 40 mL/min and add supportive care only if toxicities emerge
B. Begin preemptive dermatologic supportive care at treatment start and reinforce early reporting of rash and other new symptoms
C. No recommended prophylactic supportive care at baseline; manage AEs only after they disrupt daily activities
D. Delay targeted-therapy counseling until the first follow-up visit so the patient is not overwhelmed

4.

A patient with progressive EGFR-mutated NSCLC after osimertinib plus chemotherapy is preparing to start amivantamab plus lazertinib and asks what to expect if she were treated with subcutaneous (SC) amivantamab vs intravenous (IV) amivantamab.

Which counseling statement is most appropriate to support shared decision-making about treatment expectations?

A. SC amivantamab has a lower rate of IRR and a lower response rate
B. SC amivantamab has a similar IRR but a higher response rate
C. SC amivantamab has a lower rate of IRR and a similar response rate
D. SC amivantamab has a higher IRR and a similar response rate

5.

A patient with metastatic EGFR L858R NSCLC starts IV amivantamab plus lazertinib. At Wk 6, she reports new dyspnea.

Which action is most appropriate?

A. Reassure her and continue routine monitoring
B. Evaluate for VTE and review anticoagulation
C. Hold therapy and begin pneumonitis management
D. Wait until next restaging and reassess for symptoms

6.

Which treatment-emergent AE profile is most characteristic of datopotamab deruxtecan, a TROP2-directed ADC approved for patients with previously treated EGFR-mutated NSCLC?

A. Acneiform rash and paronychia
B. Infusion reactions and venous thromboembolism
C. Ocular surface events and stomatitis/oral mucositis
D. Persistent diarrhea and nail toxicity

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Staying the Course: Pharmacist Best Practices for Managing Adverse Events and Maintaining Therapy in EGFR-Mutated NSCLC

Nina DiPierro, PharmD, BCOP

Alia 'Lia' Lynch, PharmD, BCOP

Pretest

Please answer the questions below.

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