CE / CME
In this second of 3 video modules, an expert reviews emerging clinical evidence on CDH6-directed ADCs for the treatment of ovarian cancer, with a focus on platinum-resistant disease. The faculty examines CDH6 expression and its relationship to FRα expression, along with early-phase efficacy and safety data for investigational agents, including CUSP06 and raludotatug deruxtecan. Findings from the CUSP06-1001 and REJOICE-Ovarian01 trials, including objective response rates, response durability, activity following prior ADC treatment, dose optimization, and adverse event profiles, are highlighted. Clinical outcomes are also compared with those of other ADCs evaluated in ovarian cancer, providing context for assessing the potential role of CDH6-directed therapies and interpreting emerging evidence that may inform future treatment selection and sequencing.
Physician Assistants/Physician Associates: 0.25 AAPA Category 1 CME credit
Pharmacists: 0.25 contact hour (0.025 CEUs)
ABIM MOC: maximum of 0.25 Medical Knowledge MOC point
Physicians: maximum of 0.25 AMA PRA Category 1 Credit™
Nurse Practitioners/Nurses: 0.25 Nursing contact hour
Released: October 28, 2026
Expiration: April 27, 2027
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Provided by Clinical Care Options, LLC dba Decera Clinical Education.
This activity is supported by educational grants from Daiichi Sankyo, Inc and Merck Sharp & Dohme LLC.
Daiichi Sankyo, Inc.
Merck Sharp & Dohme, LLC
This activity is intended for oncologists, nurses, pharmacists, physician associates, and other global healthcare professionals who care for patients with ovarian cancer.
This activity is designed to equip learners with the knowledge, clinical judgment, and confidence needed to deliver high-quality, evidence-based care for patients with ovarian cancer.
Upon completion of this activity, participants should be able to:
Appraise emerging clinical evidence regarding the efficacy and safety of CDH6-targeted antibody–drug conjugates in ovarian cancer
Formulate evidence-based strategies for biomarker-informed patient selection and sequencing of CDH6-directed ADCs in ovarian cancer
Decera Clinical Education requires instructors, planners, managers, and other individuals who are in a position to control the content of this activity to disclose all financial conflicts of interest (COI) they may have with ineligible companies. All relevant COI are thoroughly vetted and mitigated according to Decera Clinical Education policy. Decera Clinical Education is committed to providing its learners with high-quality CME/CE activities and related materials that promote improvements or quality in healthcare and not a specific proprietary business interest of an ineligible company.
The faculty reported the following relevant financial relationships or relationships to products or devices they have with ineligible companies related to the content of this educational activity:
Primary AuthorDebra L. Richardson, MD: consultant/advisor/speaker: AbbVie, Araris, Corcept, Daiichi Sankyo, Genelux, GSK, Incyclix, Repare, Tubulis/Gilead.
The planners and content peer reviewers from Decera Clinical Education do not have any relevant financial relationships to disclose, except Kristi K. Orbaugh, MSN, NP, AOCNP, as noted below:
Kristi K. Orbaugh, MSN, NP, AOCNP: speaker: AstraZeneca, Boehringer Ingelheim, Bristol Myers Squibb, DSI, Exelixis, Lilly, Pfizer, Stemline.
Participation in this self-study activity should be completed in approximately 0.25 hours. To successfully complete this activity and receive credit, participants must follow these steps during the period from October 28, 2026, through April 27, 2027:
You must receive a test score of at least 65 and respond to all evaluation questions to receive a certificate. After submitting the evaluation, you may access your online certificate by selecting the certificate link on the confirmation page. Records of all CME/CE activities completed can be found on the "My Certificates" page. There are no costs/fees for this activity.
This program has been made available online.
This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. The planners of this activity do not recommend the use of any agent outside of the labeled indications.
The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of the planners. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.
Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient’s conditions and possible contraindications and/or dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.
Generative artificial intelligence (AI) tools were used for data analysis or summarization influencing content and generating transcript(s) from audio/video file. All AI-assisted content underwent human review, editing, and validation by qualified faculty and accredited education staff to ensure scientific accuracy, balance, and compliance with the ACCME Standards for Integrity and Independence in Accredited Continuing Education.
Joint Accreditation Statement

In support of improving patient care, Clinical Care Options, LLC dba Decera Clinical Education is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.
Physician Continuing Medical Education
Clinical Care Options, LLC dba Decera Clinical Education designates this enduring material for a maximum of 0.25 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Nursing Continuing Professional Development
The maximum number of hours awarded for this Nursing Continuing Professional Development activity is 0.25 contact hours.
Continuing Pharmacy Education

Clinical Care Options, LLC dba Decera Clinical Education designates this continuing education activity for 0.25 contact hours (0.025 CEUs) of the Accreditation Council for Pharmacy Education. Universal Activity Number: JA4008176-0000-26-615-H01-P
Type of Activity: Knowledge
Upon successfully completing the post-test with a score of 65% or better and the activity evaluation form, transcript information will be sent to the NABP CPE Monitor Service within 60 days.
Physician Associate Continuing Medical Education

Clinical Care Options, LLC dba Decera Clinical Education has been authorized by the American Academy of PAs (AAPA) to award AAPA Category 1 CME credit for activities planned in accordance with AAPA CME Criteria. This activity is designated for 0.25 AAPA Category 1 CME credits. Approval is valid until April 27, 2027. PAs should only claim credit commensurate with the extent of their participation.
American Board of Internal Medicine Maintenance of Certification

Successful completion of this CME activity, which includes participation in the evaluation component, enables the learner to earn up to 0.25 MOC points in the American Board of Internal Medicine’s (ABIM) Maintenance of Certification (MOC) program. It is the CME activity provider’s responsibility to submit learner completion information to ACCME for the purpose of granting ABIM MOC credit.
For ABIM MOC points, your information will be shared with the ABIM through Decera Clinical Education's Joint Accreditation Program and Activity Reporting System (JAPARS). Please allow 6-8 weeks for your MOC points to appear on your ABIM records.
By sharing your Diplomate Board ID # and DOB, you are giving Decera Clinical Education permission to use this information/data to report your participation to these Boards via the Joint Accreditation Program and Activity Reporting System (JA-PARS).
IPCE Credit Designation

This activity was planned by and for the healthcare team, and learners will receive 0.25 Interprofessional Continuing Education (IPCE) credits for learning and change.
CME Passport

The CME credits that physicians earn from this activity will be submitted to ACCME's CME Passport, a free, centralized web application where you can create a personalized account to view, track, and generate transcripts of your reported credit. Visit CME cmepassport.org to create your account.