ClinicalThought Expert Office Hours Forum: Implementing Systemic Therapy in H3K27-Altered DMG

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Released: August 24, 2026

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A recent FDA approval of a drug indicated for patients with diffuse midline glioma (DMG) with a mutation in H3K27 has led to an overhaul of how this cancer is treated in pediatric and adult patients. In this clinical forum, experts will answer questions related to the program, “Implementing Systemic Therapy in H3K27-Altered DMG: Practical Strategies to Optimize Postradiation Care.” This social media forum provides learners with ongoing access to faculty throughout the certified life of this program. Learners are encouraged to submit their questions here.

Stephen J. Bagley, MD

Carl Koschmann, MD

Karen D. Wright, MD, MS

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Welcome to this online Expert Office Hours Forum for our “Implementing Systemic Therapy in H3K27-Altered DMG: Practical Strategies to Optimize Postradiation Care” symposium, which will be held in conjunction with the 2026 Society for Neuro-Oncology (#SNO2026) Annual Meeting on November 12-15, 2026, in Philadelphia, Pennsylvania, presented by Stephen J. Bagley, MD; Carl Koschmann, MD; and Karen Wright, MD. The goal of this forum is to provide you with the opportunity to engage with the participating faculty throughout the life of the program. You can find the related educational activities here. You will be able to return to this ClinicalThought social media forum as often as you like and pose your questions and challenging cases related to the care of patients with diffuse midline glioma following the live program when you are back in the clinic. We hope that this interactive resource will provide ongoing expert feedback and guidance as you apply the workshop insights to your clinical practice, serving to reinforce concepts and address your real-world challenges related to optimizing postradiation care.

Learners, please submit your questions and challenging cases that arise after the live program has adjourned. The experts of this program will provide feedback and guidance as you return to clinic and begin applying the program’s content into practice.

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