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Diagnosing ET and PV

CME

Global Experts Discuss Diagnostic Considerations in ET and PV

Physicians: Maximum of 0.25 AMA PRA Category 1 Credit

Released: May 04, 2026

Expiration: November 03, 2026

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Please answer the questions below.
1.

A 66-year-old woman presents with fatigue and headaches. Physical examination reveals splenomegaly (1 cm below costal margin). A complete blood count demonstrates platelets 650 x 109/L, white blood cell count 6.1 g/L, hemoglobin 13 g/dL, hematocrit 42%, and normal mean corpuscular volume. Further testing reveals normal iron and C-reactive protein, with BCR-ABL1 negativity and JAK2 V617F positivity. 

Do you have enough information to make a definitive diagnosis of either ET or PV?