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Applying the Latest Data and Expert Guidance for CSF1R-Targeted Treatment of TGCT

Slideset

This downloadable slideset examines evolving treatment strategies for tenosynovial giant cell tumor (TGCT), with emphasis on individualized decision-making for patients with symptomatic, progressive, or function-limiting disease. The slideset reviews when observation, surgery, systemic therapy, or combined approaches may be appropriate; the limitations and potential morbidity of surgery, particularly in diffuse-type TGCT; and phase III evidence from the ENLIVEN and MOTION trials investigating CSF1R-targeted therapies. In addition, the slideset discusses emerging agents, treatment duration and sequencing, monitoring for progressive joint damage, and the role of multidisciplinary care and shared decision-making in balancing disease control, treatment burden, toxicity, quality of life, and preservation of joint function.

Released: September 01, 2026

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Provided by

Provided by Clinical Care Options, LLC dba Decera Clinical Education.

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Supporters

Supported by an educational grant from Daiichi Sankyo, Inc.

Daiichi Sankyo, Inc.

Target Audience

This program is intended for oncologists, physician associates, nurses, nurse practitioners, clinical nurse specialists, pharmacists, and other healthcare professionals who care for patients with tenosynovial giant cell tumors.

Learning Objectives

Upon completion of this activity, participants should be able to:

  • Evaluate current and emerging data on CSF1R-targeted therapies to inform treatment selection and sequencing for patients with TGCT

  • Coordinate multidisciplinary care approaches that involve key specialties to optimize TGCT treatment planning

Financial Disclosures

Primary Author

Emanuela Palmerini, MD, PhD: consultant/advisor/speaker: Daiichi Sankyo, Deciphera, EMD Serono, Servier, SpringWorks.

Additional Disclosures

Generative artificial intelligence (AI) tools were used for data analysis or summarization influencing content. All AI-assisted content underwent human review, editing, and validation by qualified faculty and accredited education staff to ensure scientific accuracy, balance, and compliance with the ACCME Standards for Integrity and Independence in Accredited Continuing Education.