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Next-Generation CDH6-Targeting Antibody–Drug Conjugates in Ovarian Cancer: The Science, Strategy, and Signals to Inform Clinical Readiness

Text Module

Read this text module with accompanying slides to gain insight into the emerging data for CDH6-targeting antibody–drug conjugates in ovarian cancer as well as the motivation and strategies for promoting equitable access to novel therapies and clinical trials.

Physicians: Maximum of 0.75 AMA PRA Category 1 Credit

Released: January 26, 2026

Expiration: July 25, 2026

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Provided by Clinical Care Options, LLC dba Decera Clinical Education.

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Supporters

Supported by educational grants from Daiichi Sankyo, Inc and Merck Sharp & Dohme, LLC

Daiichi Sankyo, Inc.

Merck Sharp & Dohme, LLC

Target Audience

This educational activity is intended for medical oncologists and other healthcare professionals who care for patients with ovarian cancer.

Program Learning Goal

This activity aims to improve learners’ knowledge, confidence, and competence in understanding the latest science, emerging conference and clinical trial data, and ongoing clinical trials on ADCs targeting CDH6 in ovarian cancer. 

Learning Objectives

Upon completion of this activity, participants should be able to:

  • Interpret the biologic rationale and mechanism of action for CDH6-targeting ADCs in ovarian cancer

  • Evaluate current and emerging clinical trial data on novel CDH6-targeted agents

  • Identify patients eligible for enrollment into clinical trials evaluating CDH6-targeting therapies

Disclosure

Decera Clinical Education requires instructors, planners, managers, and other individuals who are in a position to control the content of this activity to disclose all financial conflicts of interest (COI) they may have with ineligible companies. All relevant COI are thoroughly vetted and mitigated according to Decera Clinical Education policy. Decera Clinical Education is committed to providing its learners with high-quality CME/CE activities and related materials that promote improvements or quality in healthcare and not a specific proprietary business interest of an ineligible company.

The faculty reported the following relevant financial relationships or relationships to products or devices they have with ineligible companies related to the content of this educational activity:

Primary Author

Isabelle Ray-Coquard, MD, PhD, Prof, has no relevant financial relationships to disclose.

Debra L. Richardson, MD: consultant/advisor/speaker: Araris, AstraZeneca, Corcept, Daiichi Sankyo, Eisai, Genelux, Genmab, GSK, ImmunoGen/AbbVie, Incyclix, Tubulis, Zentalis; researcher (paid to institution): A2A Pharmaceuticals, Aadi, AbbVie, Acrivon, Allorian, Celsion, Daiichi Sankyo, DualityBio, GSK, Karyopharm, Mersana, Nimbus, Nurix, OnCusp, PMV Pharmaceuticals, Totus, Tubulis, Xenco; other financial or material support: Repare.

The planners and content peer reviewers from Decera Clinical Education do not have any relevant financial relationships to disclose.

Instructions for Credit

Participation in this self-study activity should be completed in approximately 0.75 hours. To successfully complete this activity and receive credit, participants must follow these steps during the period from January 26, 2026, through July 25, 2026:

  1. Login or Sign Up for an account by clicking at the top of this page.
  2. Read the target audience, learning objectives, and faculty disclosures.
  3. View and study the content in its entirety.
  4. Submit answers to the posttest questions and evaluation questions online.

You must receive a test score of at least 65 and respond to all evaluation questions to receive a certificate. After submitting the evaluation, you may access your online certificate by selecting the certificate link on the confirmation page. Records of all CME/CE activities completed can be found on the "My Certificates" page. There are no costs/fees for this activity.

Format

This program has been made available online.

Disclosure of Unlabeled Use

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. The planners of this activity do not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of the planners. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

Disclaimer

Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient’s conditions and possible contraindications and/or dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.

Accreditation

Joint Accreditation Statement

In support of improving patient care, Clinical Care Options, LLC dba Decera Clinical Education is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

Physician Continuing Medical Education

Clinical Care Options, LLC dba Decera Clinical Education designates this enduring material for a maximum of 0.75 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

CME Passport

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The CME credits that physicians earn from this activity will be submitted to ACCME's CME Passport, a free, centralized web application where you can create a personalized account to view, track, and generate transcripts of your reported CME credit. Visit www.cmepassport.org to create your account.