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Bispecific Antibodies in Relapsed/Refractory Follicular Lymphoma: Efficacy, Toxicities, and Practical Implementation

Farrukh T. Awan, MD, MS, MBA

Jennifer Crombie, MD

Activity

Introduction

How many people with FL do you provide care for in a typical month?

For those who practice in academic or community settings, please indicate your practice setting

You are preparing to initiate epcoritamab in a patient with relapsed/refractory (R/R) FL after ≥2 prior lines of therapy. What would you recommend when beginning treatment?

Based on the OLYMPIA-5 trial safety lead-in results exploring odronextamab plus lenalidomide, which of the following findings best reflects a key consideration for safely integrating this bispecific combination regimen into future clinical practice?

A 60-year-old patient with R/R FL is receiving mosunetuzumab. During cycle 1 step-up dosing, the patient develops a fever of 38.8°C without hypotension or hypoxia. Symptoms resolved with antipyretics within 24 hours. Based on current guidelines, how would you manage this patient now?