Ask AI

The Pain Briefcase: Unpacking the Pathophysiology of Pain

Text Module
Text Module Start Activity
This activity is available for 0.25 CME/CE credit(s).

Released: October 28, 2026

Expiration: October 27, 2027

See Activity Collection

Acute pain management increasingly requires an individualized, multimodal approach that considers both pain biology and the psychological and social factors influencing each patient’s experience. This activity explores pain assessment, ascending and descending pain pathways, opioid-sparing strategies, and the emerging role of peripheral sodium-channel inhibition, including NaV1.8-targeted therapy, in improving acute pain management.

Pathophysiology of Pain

Pre Assessment

Assess your current knowledge and clinical approach before beginning your text module.
1.

How many people with acute pain do you provide care for in a typical month?

2.

For those who practice in academic or community settings, please indicate your practice setting:

3.

A patient with moderate to severe postoperative pain wishes to minimize opioid use and takes several chronic medications. You are considering suzetrigine as part of multimodal analgesia. Which consideration is most appropriate for you to proceed with the treatment plan?