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Novel C5 Inhibitors in Generalized Myasthenia Gravis: Using Mechanism to Inform Management

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Research shows that approximately 62% of patients with myasthenia gravis receiving chronic treatment continued to experience moderate to severe symptoms, underscoring the need for more individualized disease management. Through these slides, explore evidence for approved and emerging C5 inhibitors, the role of FcRn-directed approaches, and practical considerations such as safety, treatment burden, response assessment, switching, access, and patient preferences.

Released: August 31, 2026

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Provided by

Provided by Clinical Care Options, LLC dba Decera Clinical Education

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Supporters

This activity is supported by an independent medical education grant from Regeneron Pharmaceuticals, Inc.

Regeneron Pharmaceuticals, Inc

Target Audience

This activity is intended for neurologists, neuromuscular specialists, advanced practice providers, nurses, physician associates, and pharmacists caring for patients with MG.

Learning Objectives

Upon completion of this activity, participants should be able to:

  • Summarize the unmet medical needs in the care of people living with MG, including those who do not adequately respond to first-line therapies

  • Differentiate novel C5 inhibitors based on their clinical characteristics, such as efficacy, safety profiles, and schedules/routes of administration

  • Formulate individualized care plans for people with gMG that integrate evidence-based use of C5 inhibitors, considering mechanism of action, efficacy, safety, and evolving clinical roles to support long-term adherence and improved quality of life

Additional Disclosures

Generative artificial intelligence (AI) tools were used fordrafting educational content, revising or refining educational content, generating clinical case(s) or scenario(s), and drafting assessment question(s) and/or rationale(s). All AI-assisted content underwent human review, editing, and validation by qualified faculty and accredited education staff to ensure scientific accuracy, balance, and compliance with the ACCME Standards for Integrity and Independence in Accredited Continuing Education.