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Breaking the Therapeutic Ceiling in Schizophrenia Care

Podcast

The introduction of muscarinic receptor agonism offers a new approach to schizophrenia treatment beyond traditional dopamine D2 receptor blockade. This expert-led podcast reviews the mechanisms and emerging evidence for muscarinic therapies, with a focus on xanomeline/trospium. Discussion of efficacy, safety, and practical prescribing considerations explores how these treatments may expand therapeutic options for patients with schizophrenia.

Released: November 03, 2026

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Provided by

Provided by Clinical Care Options, LLC dba Decera Clinical Education

 

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Supporters

Supported by an educational grant from Bristol Myers Squibb. 

Bristol Myers Squibb

Target Audience

This activity is intended for healthcare professionals caring for patients with schizophrenia including psychiatrists, physicians, nurse practitioners, physician associates, registered nurses, pharmacists, social workers, and psychologists.

Learning Objectives

Upon completion of this activity, participants should be able to:

  • Explain the clinical utility of novel antipsychotics to address unmet needs of current schizophrenia treatments

  • Define the distinctive mechanisms of action and pharmacokinetic characteristics of novel and emerging therapeutic agents for schizophrenia that extend beyond traditional antidopaminergic approaches

  • Integrate novel therapeutic options into treatment plans for appropriate patients with schizophrenia based on current clinical evidence

  • Counsel patients on optimal administration and side effect management for schizophrenia therapies to maximize adherence

  • Design strategies to holistically assess the range symptoms in schizophrenia and the impact of therapy on patient outcomes

Financial Disclosures

Primary Author

Rebecca DePalma, DMSc, PA-C: consultant/advisor/speaker: AbbVie, Bristol Myers Squibb.

Additional Disclosures

Generative artificial intelligence (AI) tools were used for revising or refining educational content and generating transcripts from audio/video files. All AI-assisted content underwent human review, editing, and validation by qualified faculty and accredited education staff to ensure scientific accuracy, balance, and compliance with the ACCME Standards for Integrity and Independence in Accredited Continuing Education.