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The Primary Challenge: Making Adjunctive Add Up in MDD

Slideset

Residual symptoms such as anhedonia, cognitive dysfunction, and sleep disturbance can persist despite improvement in major depressive disorder, complicating efforts to achieve functional recovery. This downloadable slideset examines when to optimize, switch, or augment treatment and compares evidence for adjunctive therapies. Learners will review practical considerations for managing persistent symptoms, treatment resistance, and patients who may require specialty referrals.

Released: October 06, 2026

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Provided by

Provided by Clinical Care Options, LLC dba Decera Clinical Education

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Supporters

This activity is supported by an educational grant from Intra-Cellular Therapies, Inc.

Intra-Cellular Therapies, Inc.

Target Audience

This activity is intended for healthcare professionals caring for patients with major depressive disorder, including physicians (psychiatrists and family medicine/primary care), nurse practitioners, physician associates, registered nurses, pharmacists, and psychologists.

Learning Objectives

Upon completion of this activity, participants should be able to:

  • Assess optimal timing and clinical rationale for switching or augmenting treatment in patients with MDD

  • Evaluate the pharmacologic profiles, efficacy, and safety of approved adjunctive therapies for adults with MDD that improve residual symptoms, including anhedonia and cognitive impairment

  • Apply current guideline-based and evidence-based strategies to optimize dosing and titration of adjunctive therapies for adults with MDD who exhibit residual symptoms

  • Implement strategies for optimizing the management of persistent symptoms for complex or special populations with MDD to optimize long-term outcomes and functional recovery

Additional Disclosures

Generative artificial intelligence (AI) tools were used for revising or refining educational content. All AI-assisted content underwent human review, editing, and validation by qualified faculty and accredited education staff to ensure scientific accuracy, balance, and compliance with the ACCME Standards for Integrity and Independence in Accredited Continuing Education.