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When patients raise questions about vaccines, how a healthcare professional responds can shape whether the conversation builds trust or shuts it down. This downloadable infographic uses a 6-step, evidence-informed roadmap to show how empathy, open-ended questions, permission-based explanations, and a clear, personalized recommendation can move vaccine conversations forward. Follow one continuous patient–HCP exchange to compare responses that fall short, work better, or best support informed decision-making.